Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralization

• Mohamed Hamed Misbah,
• Mercedes Santos,
• Luis Quintanilla,
• Christina Günter,
• Matilde Alonso,
• Andreas Taubert and
• José Carlos Rodríguez-Cabello

Beilstein J. Nanotechnol. 2017, 8, 772–783, doi:10.3762/bjnano.8.80

• , D-14476 Potsdam, Germany Institute of Chemistry, University of Potsdam, D-14476 Potsdam, Germany 10.3762/bjnano.8.80 Abstract Understanding the mechanisms responsible for generating different phases and morphologies of calcium phosphate by elastin-like recombinamers is supreme for bioengineering of

• described. Thus, two different hydroxyapatite morphologies (cauliflower- and plate-like) have been formed. Overall, this study shows that crosslinking elastin-like recombinamers leads to interesting matrix materials for the generation of calcium phosphate composites with potential applications as

• biomaterials. Keywords: calcium phosphate; elastin-like recombinamers; hydroxyapatite; mineralization; SNA15; Introduction Combination of the specific properties of two materials is often a key to generating a new material, whose properties are superior to those of its individual components, with improved